RAS
renin–angiotensin system
Instead, ApoE4 downregulates ACE2 protein expression and subsequently the dysregulation of renin–angiotensin system (RAS) may provide explanation by which ApoE4 exacerbates COVID-19 disease.
However, even given that COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin system (RAS), we were still far from understanding the complexity of the mechanisms which are controlled by ACE2 in different cell types.
Sumber pustaka atau data yang digunakan dalam penelitian ini didapatkan dari publikasi ilmiah baik internasional maupun nasional yang tercantum dalam Pubmed, Science Direct, dan Google Scholar dengan kata kunci “COVID-19, preeclampsia, SARS-CoV-2, angiotensin converting enzyme (ACE2), renin-angiotensin system (RAS)”.
Infeksi COVID-19 dapat memicu terjadinya down-regulasi pada Renin-Angiotensin System (RAS) akibat pengikatan SARS-CoV-2 pada reseptor ACE2.
AbstractSARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound enzyme of the “alternative” (alt) renin-angiotensin system (RAS).
It has now been established that a risk of a severe course of COVID-19 is not so much a patient's age itself, but so-called age-related diseases; the renin-angiotensin system (RAS) is directly or indirectly involved into their development.
The impact of anti-hypertensives in comorbidities is due to the expression of renin-angiotensin system (RAS) in several tissues and body fluids.
Many of these patients receive renin-angiotensin system (RAS) inhibiting therapy, and evidence suggests that treatment with angiotensin II receptor blockers (ARBs) could attenuate SARS-CoV-induced acute respiratory distress syndrome, and ACE inhibitors and ARBs have been suggested to alleviate COVID-19 pulmonary manifestations.