NIV
non-invasive ventilation
However, its utility among spontaneously breathing patients is still debated.MethodsIn an open-label randomized controlled trial, we enrolled patients hospitalized with mild COVID-19 pneumonia, whose PaO2/FiO2 ratio was 200 mmHg and who did not require mechanical ventilation (MV) or non-invasive ventilation (NIV) at hospital admission.
Depending on the type of oxygen support, three groups of patients were formed: group 1 (n=168) — nasal oxygen insufflation; group 2 (n=92) — non-invasive ventilation (NIV); group 3 (n=45) — artificial ventilation (AV).
Of the four patients who had fall in oxygen saturation two were admitted in Intensive Care Unit (ICU) and one required Non Invasive Ventilation (NIV).
Secondary outcomes included symptom remission rate, time to symptom remission, length of hospital stay (LOS), requirement of oxygen therapy, requirement of non-invasive ventilation (NIV), requirement of invasive mechanical ventilation (IMV), days of MV, peripheral arterial haemoglobin oxygen saturation (SpaO ), biomarkers of inflammatory dysregulation and pulmonary imaging changes.
Non-Invasive Respiratory Support (NRS) as Continuous Positive Airway Pressure (CPAP) and/or Non-Invasive Ventilation (NIV) has been proven as effective in the management of SARS-CoV-2-related ARDS.